Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity

Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly required. This study presents the design, synthesis, and...

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Detalles Bibliográficos
Autores principales: Pallabothula, Vinod Sukanth Kumar, Kerda, Marek, Juhás, Martin, Janďourek, Ondřej, Konečná, Klára, Bárta, Pavel, Paterová, Pavla, Zitko, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687610/
https://www.ncbi.nlm.nih.gov/pubmed/36358911
http://dx.doi.org/10.3390/biom12111561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687610/
https://www.ncbi.nlm.nih.gov/pubmed/36358911
http://dx.doi.org/10.3390/biom12111561

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