Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway

Cardiac fibrosis is an important pathological process in many diseases. Wdr5 catalyzes the trimethylation of lysine K4 on histone H3. The effects of Wdr5 on the cardiac fibrosis phenotype and the activation or transformation of cardiac fibroblasts were investigated by Ang-II-infused mice by osmotic...

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Detalles Bibliográficos
Autores principales: Yuan, Jiali, Peng, Hong, Mo, Binfeng, Yin, Chengye, Fang, Guojian, Li, Yingze, Wang, Yuepeng, Chen, Renhua, Wang, Qunshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687631/
https://www.ncbi.nlm.nih.gov/pubmed/36358925
http://dx.doi.org/10.3390/biom12111574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687631/
https://www.ncbi.nlm.nih.gov/pubmed/36358925
http://dx.doi.org/10.3390/biom12111574

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