Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR: Density Functional Theory, Molecular Docking and Molecular Dynamics Simulation Studies

Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the treatment of renal inflammatory diseases, acting via VEGFR 2 receptor. To date, most FDA-approved tyrosine kinase (TK) inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales: Bilal, Muhammad Sajjad, Ejaz, Syeda Abida, Zargar, Seema, Akhtar, Naveed, Wani, Tanveer A., Riaz, Naheed, Aborode, Adullahi Tunde, Siddique, Farhan, Altwaijry, Nojood, Alkahtani, Hamad M., Umar, Haruna Isiyaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687636/
https://www.ncbi.nlm.nih.gov/pubmed/36358960
http://dx.doi.org/10.3390/biom12111612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687636/
https://www.ncbi.nlm.nih.gov/pubmed/36358960
http://dx.doi.org/10.3390/biom12111612

Ejemplares similares