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Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR: Density Functional Theory, Molecular Docking and Molecular Dynamics Simulation Studies

Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the treatment of renal inflammatory diseases, acting via VEGFR 2 receptor. To date, most FDA-approved tyrosine kinase (TK) inhibitor...

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Detalles Bibliográficos
Autores principales:	Bilal, Muhammad Sajjad, Ejaz, Syeda Abida, Zargar, Seema, Akhtar, Naveed, Wani, Tanveer A., Riaz, Naheed, Aborode, Adullahi Tunde, Siddique, Farhan, Altwaijry, Nojood, Alkahtani, Hamad M., Umar, Haruna Isiyaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687636/ https://www.ncbi.nlm.nih.gov/pubmed/36358960 http://dx.doi.org/10.3390/biom12111612

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