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The Binding Specificity of PAB1 with Poly(A) mRNA, Regulated by Its Structural Folding
The poly(A)-binding protein cytoplasmic 1 (PAB1 or PABPC1) protein is associated with the long poly(A) mRNA tails, inducing stability. Herein, we investigated the dynamics of the PABPC1 protein, along with tracing its mRNA binding specificity. During molecular dynamics simulations (MDS), the R176-Y4...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687780/ https://www.ncbi.nlm.nih.gov/pubmed/36428549 http://dx.doi.org/10.3390/biomedicines10112981 |