Discovery of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 2-(5-(4′-Chloro-[1,1′-biphenyl]-4-yl)-4H-1,2,4-triazol-3-yl)ethan-1-amine (LK00764) for the Treatment of Psychotic Disorders

A focused in-house library of about 1000 compounds comprising various heterocyclic motifs in combination with structural fragments similar to β-phenylethylamine or tyramine was screened for the agonistic activity towards trace amine-associated receptor 1 (TAAR1). The screening yielded two closely re...

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Detalles Bibliográficos
Autores principales: Krasavin, Mikhail, Lukin, Alexey, Sukhanov, Ilya, Gerasimov, Andrey S., Kuvarzin, Savelii, Efimova, Evgeniya V., Dorofeikova, Mariia, Nichugovskaya, Anna, Matveev, Andrey, Onokhin, Kirill, Zakharov, Konstantin, Gureev, Maxim, Gainetdinov, Raul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687812/
https://www.ncbi.nlm.nih.gov/pubmed/36359001
http://dx.doi.org/10.3390/biom12111650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687812/
https://www.ncbi.nlm.nih.gov/pubmed/36359001
http://dx.doi.org/10.3390/biom12111650

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