Cargando…

Comparative Study of Cytotoxic and Membranotropic Properties of Betulinic Acid-F16 Conjugate on Breast Adenocarcinoma Cells (MCF-7) and Primary Human Fibroblasts

The present study evaluates the cytotoxicity of a previously synthesized conjugate of betulinic acid (BA) with the penetrating cation F16 on breast adenocarcinoma (MCF-7) and human fibroblast (HF) cell lines, and also shows the mechanism underlying its membranotropic action. It was confirmed that th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Belosludtsev, Konstantin N., Ilzorkina, Anna I., Belosludtseva, Natalia V., Sharapov, Vyacheslav A., Penkov, Nikita V., Serov, Dmitriy A., Karagyaur, Maxim N., Nedopekina, Darya A., Davletshin, Eldar V., Solovieva, Marina E., Spivak, Anna Yu, Kuzmina, Ulyana Sh., Vakhitova, Yulia V., Akatov, Vladimir S., Dubinin, Mikhail V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687851/ https://www.ncbi.nlm.nih.gov/pubmed/36428470 http://dx.doi.org/10.3390/biomedicines10112903

Ejemplares similares

Effect of F16-Betulin Conjugate on Mitochondrial Membranes and Its Role in Cell Death Initiation
por: Dubinin, Mikhail V., et al.
Publicado: (2021)

Conjugation of Triterpenic Acids of Ursane and Oleanane Types with Mitochondria-Targeting Cation F16 Synergistically Enhanced Their Cytotoxicity against Tumor Cells
por: Dubinin, Mikhail V., et al.
Publicado: (2023)

Pharmacological and Genetic Suppression of VDAC1 Alleviates the Development of Mitochondrial Dysfunction in Endothelial and Fibroblast Cell Cultures upon Hyperglycemic Conditions
por: Belosludtsev, Konstantin N., et al.
Publicado: (2023)

Alterations in Mitochondrial Morphology and Quality Control in Primary Mouse Lung Microvascular Endothelial Cells and Human Dermal Fibroblasts under Hyperglycemic Conditions
por: Belosludtseva, Natalia V., et al.
Publicado: (2023)

Alisporivir Normalizes Mitochondrial Function of Primary Mouse Lung Endothelial Cells Under Conditions of Hyperglycemia
por: Starinets, Vlada S., et al.
Publicado: (2022)

Conjugation of Natural Triterpenic Acids with Delocalized Lipophilic Cations: Selective Targeting Cancer Cell Mitochondria
por: Spivak, Anna Yu., et al.
Publicado: (2021)

Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity
por: Nedopekina, Darya A., et al.
Publicado: (2017)

Effect of Modified Levopimaric Acid Diene Adducts on Mitochondrial and Liposome Membranes
por: Dubinin, Mikhail V., et al.
Publicado: (2022)

Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient mdx Mice
por: Dubinin, Mikhail V., et al.
Publicado: (2021)

Effect of the MPT Pore Inhibitor Alisporivir on the Development of Mitochondrial Dysfunction in the Heart Tissue of Diabetic Mice
por: Belosludtseva, Natalia V., et al.
Publicado: (2021)

Effect of Dapagliflozin on the Functioning of Rat Liver Mitochondria In Vitro
por: Belosludtseva, N. V., et al.
Publicado: (2021)

Membranotropic Cell Penetrating Peptides: The Outstanding Journey
por: Falanga, Annarita, et al.
Publicado: (2015)

Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
por: Belosludtsev, Konstantin N., et al.
Publicado: (2020)

Physiologically Active Compounds Based on Membranotropic Cage Carriers–Derivatives of Adamantane and Polyhedral Boron Clusters (Review)
por: Avdeeva, V. V., et al.
Publicado: (2022)

Effect of Fusidic Acid and Some Nitrogen-Containing Derivatives on Liposomal and Mitochondrial Membranes
por: Dubinin, Mikhail V., et al.
Publicado: (2023)

Effect of Chronic Treatment with Uridine on Cardiac Mitochondrial Dysfunction in the C57BL/6 Mouse Model of High-Fat Diet–Streptozotocin-Induced Diabetes
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)

Transport of Ca(2+) and Ca(2+)-Dependent Permeability Transition in Rat Liver Mitochondria under the Streptozotocin-Induced Type I Diabetes
por: Belosludtsev, Konstantin N., et al.
Publicado: (2019)

gH625: A milestone in understanding the many roles of membranotropic peptides
por: Galdiero, Stefania, et al.
Publicado: (2015)

Harnessing the Role of Bacterial Plasma Membrane Modifications for the Development of Sustainable Membranotropic Phytotherapeutics
por: Panda, Gayatree, et al.
Publicado: (2022)

Hydration Shells of DNA from the Point of View of Terahertz Time-Domain Spectroscopy
por: Penkova, Nadezda A., et al.
Publicado: (2021)

The Effect of Deflazacort Treatment on the Functioning of Skeletal Muscle Mitochondria in Duchenne Muscular Dystrophy
por: Dubinin, Mikhail V., et al.
Publicado: (2020)

The Effect of S-15176 Difumarate Salt on Ultrastructure and Functions of Liver Mitochondria of C57BL/6 Mice with Streptozotocin/High-Fat Diet-Induced Type 2 Diabetes
por: Belosludtseva, Natalia V., et al.
Publicado: (2020)

Alisporivir Improves Mitochondrial Function in Skeletal Muscle of mdx Mice but Suppresses Mitochondrial Dynamics and Biogenesis
por: Dubinin, Mikhail V., et al.
Publicado: (2021)

Alisporivir Treatment Alleviates Mitochondrial Dysfunction in the Skeletal Muscles of C57BL/6NCrl Mice with High-Fat Diet/Streptozotocin-Induced Diabetes Mellitus
por: Belosludtsev, Konstantin N., et al.
Publicado: (2021)

S-15176 Difumarate Salt Can Impair Mitochondrial Function through Inhibition of the Respiratory Complex III and Permeabilization of the Inner Mitochondrial Membrane
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)

Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids
por: Komissarova, N. G., et al.
Publicado: (2021)

Eradication of Candida albicans persister cell biofilm by the membranotropic peptide gH625
por: Galdiero, Emilia, et al.
Publicado: (2020)

Analytical probing of membranotropic effects of antimicrobial copper nanoparticles on lipid vesicles as membrane models
por: Izzi, Margherita, et al.
Publicado: (2023)

Differences in the Formation of Reactive Oxygen Species and Their Cytotoxicity between Thiols Combined with Aqua- and Cyanocobalamins
por: Shatalin, Yuri V., et al.
Publicado: (2022)

Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives
por: Spivak, Anna, et al.
Publicado: (2018)

Hydroxycobalamin catalyzes the oxidation of diethyldithiocarbamate and increases its cytotoxicity independently of copper ions
por: Solovieva, M.E., et al.
Publicado: (2018)

Novel A-Ring Chalcone Derivatives of Oleanolic and Ursolic Amides with Anti-Proliferative Effect Mediated through ROS-Triggered Apoptosis
por: Khusnutdinova, Elmira, et al.
Publicado: (2021)

Transport of Ca(2+) and Ca(2+)-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia
por: Belosludtsev, Konstantin N., et al.
Publicado: (2020)

Dimerization in tailoring uptake efficacy of the HSV-1 derived membranotropic peptide gH625
por: Falanga, Annarita, et al.
Publicado: (2017)

Membrane insertion of the three main membranotropic sequences from SARS-CoV S2 glycoprotein
por: Guillén, Jaime, et al.
Publicado: (2008)

Methods of Analysis and Identification of Betulin and Its Derivatives
por: Takibayeva, Altynaray T., et al.
Publicado: (2023)

Methods of Betulin Extraction from Birch Bark
por: Demets, Olga V., et al.
Publicado: (2022)

Catalytic Sulfation of Betulin with Sulfamic Acid: Experiment and DFT Calculation
por: Kazachenko, Aleksandr S., et al.
Publicado: (2022)

Pharmacological Potential of Betulin as a Multitarget Compound
por: Adepoju, Feyisayo O., et al.
Publicado: (2023)

The Short-Term Opening of Cyclosporin A-Independent Palmitate/Sr(2+)-Induced Pore Can Underlie Ion Efflux in the Oscillatory Mode of Functioning of Rat Liver Mitochondria
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7g6i9437k7stc0gbjtscprhj46