Proline-Rich Region II (PRR2) Plays an Important Role in Tau–Glycan Interaction: An NMR Study

(1) Background: Prion-like transcellular spreading of tau pathology in Alzheimer’s disease (AD) is mediated by tau binding to the cell-surface glycan heparan sulfate (HS). However, the structural determinants for tau–HS interaction are not well understood. (2) Methods and Results: Binding-site mappi...

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Detalles Bibliográficos
Autores principales: Murray, Anqesha, Yan, Lufeng, Gibson, James M., Liu, Jian, Eliezer, David, Lippens, Guy, Zhang, Fuming, Linhardt, Robert J., Zhao, Jing, Wang, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687896/
https://www.ncbi.nlm.nih.gov/pubmed/36358923
http://dx.doi.org/10.3390/biom12111573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687896/
https://www.ncbi.nlm.nih.gov/pubmed/36358923
http://dx.doi.org/10.3390/biom12111573

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