Proteomic Profiling Reveals Increased Glycolysis, Decreased Oxidoreductase Activity and Fatty Acid Degradation in Skin Derived Fibroblasts from LHON Patients Bearing m.G11778A

LHON is a common blinding inherited optic neuropathy caused by mutations in mitochondrial genes. In this study, by using skin fibroblasts derived from LHON patients with the most common m.G11778A mutation and healthy objects, we performed proteomic analysis to document changes in molecular proteins,...

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Detalles Bibliográficos
Autores principales: Yao, Shun, Zhang, Xiaoli, Jin, Xiuxiu, Yang, Mingzhu, Li, Ya, Yang, Lin, Xu, Jin, Lei, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687919/
https://www.ncbi.nlm.nih.gov/pubmed/36358916
http://dx.doi.org/10.3390/biom12111568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687919/
https://www.ncbi.nlm.nih.gov/pubmed/36358916
http://dx.doi.org/10.3390/biom12111568

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