Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome

Structural, functional, and molecular alterations in excitatory spines are a common hallmark of many neurodevelopmental disorders including intellectual disability and autism. Here, we describe an optimized methodology, based on combined use of DiI and immunofluorescence, for rapid and sensitive cha...

Descripción completa

Detalles Bibliográficos
Autores principales: Speranza, Luisa, Filiz, Kardelen Dalım, Goebel, Sarah, Perrone-Capano, Carla, Pulcrano, Salvatore, Volpicelli, Floriana, Francesconi, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687937/
https://www.ncbi.nlm.nih.gov/pubmed/36359212
http://dx.doi.org/10.3390/biomedicines10112692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687937/
https://www.ncbi.nlm.nih.gov/pubmed/36359212
http://dx.doi.org/10.3390/biomedicines10112692

Ejemplares similares