T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer

SIMPLE SUMMARY: The canonical methods of TCR gene delivery in pre-clinical and clinical applications are based on viral transduction of full-coding sequences, including α- and β-chains recognizing tumor-specific antigens and tumor-associated antigens. As the transduced α- and β-chains may mispair wi...

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Detalles Bibliográficos
Autores principales: Xue, Busheng, von Heyking, Kristina, Gassmann, Hendrik, Poorebrahim, Mansour, Thiede, Melanie, Schober, Kilian, Mautner, Josef, Hauer, Julia, Ruland, Jürgen, Busch, Dirk H., Thiel, Uwe, Burdach, Stefan E. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688113/
https://www.ncbi.nlm.nih.gov/pubmed/36428578
http://dx.doi.org/10.3390/cancers14225485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688113/
https://www.ncbi.nlm.nih.gov/pubmed/36428578
http://dx.doi.org/10.3390/cancers14225485

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