Structure/Function Studies on the Activation Motif of Two Non-Mammalian Mrap1 Orthologs, and Observations on the Phylogeny of Mrap1, Including a Novel Characterization of an Mrap1 from the Chondrostean Fish, Polyodon spathula

In derived bony vertebrates, activation of the melanocortin-2 receptor (Mc2r) by its ACTH ligand requires chaperoning by the Mc2r accessory protein (Mrap1). The N-terminal domain of the non-mammalian tetrapod MRAP1 from chicken (c; Gallus gallus) has the putative activation motif, W(18)D(19)Y(20)I(2...

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Detalles Bibliográficos
Autores principales: Dores, Robert M., McKinley, Greer, Meyers, Audrey, Martin, Morgan, Shaughnessy, Ciaran A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688151/
https://www.ncbi.nlm.nih.gov/pubmed/36421695
http://dx.doi.org/10.3390/biom12111681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688151/
https://www.ncbi.nlm.nih.gov/pubmed/36421695
http://dx.doi.org/10.3390/biom12111681

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