The Effect of an α-7 Nicotinic Allosteric Modulator PNU120596 and NMDA Receptor Antagonist Memantine on Depressive-like Behavior Induced by LPS in Mice: The Involvement of Brain Microglia †

Nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR, play a critical role in neuroinflammation and microglial activation associated with major depressive disorder (MDD). Microglial quinolinic acid (QUIN), which is synthesized by 3-hydroxyanthranilic acid dioxygenase (HAAO), is an N...

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Detalles Bibliográficos
Autores principales: Alzarea, Sami, Abbas, Muzaffar, Ronan, Patrick J., Lutfy, Kabirullah, Rahman, Shafiqur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688168/
https://www.ncbi.nlm.nih.gov/pubmed/36358419
http://dx.doi.org/10.3390/brainsci12111493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688168/
https://www.ncbi.nlm.nih.gov/pubmed/36358419
http://dx.doi.org/10.3390/brainsci12111493

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