Cargando…

Tumor Microenvironment Immunosuppression: A Roadblock to CAR T-Cell Advancement in Solid Tumors

Chimeric antigen receptor (CAR) T cells are an exciting advancement in cancer immunotherapy, with striking success in hematological cancers. However, in solid tumors, the unique immunosuppressive elements of the tumor microenvironment (TME) contribute to the failure of CAR T cells. This review discu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnson, Abigail, Townsend, Michelle, O’Neill, Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688327/ https://www.ncbi.nlm.nih.gov/pubmed/36429054 http://dx.doi.org/10.3390/cells11223626

Ejemplares similares

Roadblocks to success for RNA CARs in solid tumors
por: Singh, Nathan, et al.
Publicado: (2015)

Advances in Nanotechnology Development to Overcome Current Roadblocks in CAR-T Therapy for Solid Tumors
por: Mi, Juan, et al.
Publicado: (2022)

CAR T Cell Locomotion in Solid Tumor Microenvironment
por: Nguyen, Duy T., et al.
Publicado: (2022)

Current advances and challenges in CAR T-Cell therapy for solid tumors: tumor-associated antigens and the tumor microenvironment
por: Yan, Ting, et al.
Publicado: (2023)

Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy
por: Liu, Zaoqu, et al.
Publicado: (2022)

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment
por: Scarfò, Irene, et al.
Publicado: (2017)

Engineering strategies to overcome the current roadblocks in CAR T cell therapy
por: Rafiq, Sarwish, et al.
Publicado: (2019)

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment
por: Wang, Yi, et al.
Publicado: (2019)

Recent Advances in CAR-Based Solid Tumor Immunotherapy
por: Shin, Min Hwa, et al.
Publicado: (2023)

The expansion of targetable biomarkers for CAR T cell therapy
por: Townsend, Michelle H., et al.
Publicado: (2018)

Advances and Hurdles in CAR T Cell Immune Therapy for Solid Tumors
por: Boccalatte, Francesco, et al.
Publicado: (2022)

NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development
por: Bashiri Dezfouli, Ali, et al.
Publicado: (2021)

Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors
por: Zhang, Hongru, et al.
Publicado: (2022)

CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment
por: Martinez, Marina, et al.
Publicado: (2019)

Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors
por: Balta, Emre, et al.
Publicado: (2021)

Exosome-Mediated Immunosuppression in Tumor Microenvironments
por: Xie, Qi-Hui, et al.
Publicado: (2022)

CAR T cells in solid tumors: challenges and opportunities
por: Marofi, Faroogh, et al.
Publicado: (2021)

CAR-NK Cells in the Treatment of Solid Tumors
por: Wrona, Ewa, et al.
Publicado: (2021)

CAR T-Cell Therapy in Children with Solid Tumors
por: Kulczycka, Marika, et al.
Publicado: (2023)

Advances in Hypofractionated Irradiation-Induced Immunosuppression of Tumor Microenvironment
por: Wang, Yuxia
Publicado: (2021)

Advances and roadblocks in the treatment of malaria
por: Hanboonkunupakarn, Borimas, et al.
Publicado: (2020)

Innovative CAR-T Cell Therapy for Solid Tumor; Current Duel between CAR-T Spear and Tumor Shield
por: Jo, Yuna, et al.
Publicado: (2020)

The roles of curcumin in regulating the tumor immunosuppressive microenvironment
por: Wang, Yizhi, et al.
Publicado: (2020)

Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment
por: Huang, Yanyu, et al.
Publicado: (2021)

Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma
por: Uckun, Fatih M.
Publicado: (2021)

New Strategies for the Treatment of Solid Tumors with CAR-T Cells
por: Zhang, Hao, et al.
Publicado: (2016)

Current Progress in CAR-T Cell Therapy for Solid Tumors
por: Ma, Shuo, et al.
Publicado: (2019)

Hurdles to breakthrough in CAR T cell therapy of solid tumors
por: Marofi, Faroogh, et al.
Publicado: (2022)

Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment
por: Titov, Aleksei, et al.
Publicado: (2020)

Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and tumor microenvironment, overcoming multiple obstacles of CAR T therapy for solid tumors
por: Wang, Yufeng, et al.
Publicado: (2023)

Enhancing the Efficacy of CAR T Cells in the Tumor Microenvironment of Pancreatic Cancer
por: Henze, Janina, et al.
Publicado: (2020)

CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities
por: Kankeu Fonkoua, Lionel A., et al.
Publicado: (2022)

Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment
por: Sun, Bo, et al.
Publicado: (2020)

CAR-T: a potential gene carrier targeting solid tumor immune microenvironment
por: Wang, Minjie, et al.
Publicado: (2021)

CAR-T cells: the long and winding road to solid tumors
por: D’Aloia, Maria Michela, et al.
Publicado: (2018)

Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment
por: Wang, Yufeng, et al.
Publicado: (2023)

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
por: Maalej, Karama Makni, et al.
Publicado: (2023)

Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma
por: Terry, Rachael L., et al.
Publicado: (2021)

CAR-T cells and BiTEs in solid tumors: challenges and perspectives
por: Edeline, Julien, et al.
Publicado: (2021)

CAR T cell therapy in solid tumors: a short review
por: Umut, Öykü, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tlfa6nqr3ghm61q215sk35unif