Identification and Analysis of Small Molecule Inhibitors of CRISPR-Cas9 in Human Cells

Genome editing tools based on CRISPR–Cas systems can repair genetic mutations in situ; however, off-target effects and DNA damage lesions that result from genome editing remain major roadblocks to its full clinical implementation. Protein and chemical inhibitors of CRISPR–Cas systems may reduce off-...

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Detalles Bibliográficos
Autores principales: Yang, Yue, Li, Donghua, Wan, Fen, Chen, Bohong, Wu, Guanglan, Li, Feng, Ren, Yanliang, Liang, Puping, Wan, Jian, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688475/
https://www.ncbi.nlm.nih.gov/pubmed/36429003
http://dx.doi.org/10.3390/cells11223574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688475/
https://www.ncbi.nlm.nih.gov/pubmed/36429003
http://dx.doi.org/10.3390/cells11223574

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