Cargando…

Identification and Analysis of Small Molecule Inhibitors of CRISPR-Cas9 in Human Cells

Genome editing tools based on CRISPR–Cas systems can repair genetic mutations in situ; however, off-target effects and DNA damage lesions that result from genome editing remain major roadblocks to its full clinical implementation. Protein and chemical inhibitors of CRISPR–Cas systems may reduce off-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yue, Li, Donghua, Wan, Fen, Chen, Bohong, Wu, Guanglan, Li, Feng, Ren, Yanliang, Liang, Puping, Wan, Jian, Songyang, Zhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688475/ https://www.ncbi.nlm.nih.gov/pubmed/36429003 http://dx.doi.org/10.3390/cells11223574

Ejemplares similares

CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo
por: Li, Minyan, et al.
Publicado: (2015)

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
por: Liang, Puping, et al.
Publicado: (2015)

Single AAV-Mediated CRISPR-SaCas9 Inhibits HSV-1 Replication by Editing ICP4 in Trigeminal Ganglion Neurons
por: Chen, Yuxi, et al.
Publicado: (2020)

Live cell imaging and proteomic profiling of endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated knock-in
por: Chen, Bohong, et al.
Publicado: (2020)

Repurposing type I–F CRISPR–Cas system as a transcriptional activation tool in human cells
por: Chen, Yuxi, et al.
Publicado: (2020)

Author Correction: Repurposing type I–F CRISPR–Cas system as a transcriptional activation tool in human cells
por: Chen, Yuxi, et al.
Publicado: (2020)

Systematic identification of CRISPR off-target effects by CROss-seq
por: Li, Yan, et al.
Publicado: (2022)

Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells
por: Li, Guoling, et al.
Publicado: (2017)

Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing
por: Zhang, Xiya, et al.
Publicado: (2021)

Rational guide RNA engineering for small-molecule control of CRISPR/Cas9 and gene editing
por: Liu, Xingyu, et al.
Publicado: (2022)

A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing
por: Zhang, Weina, et al.
Publicado: (2020)

Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency
por: Bermudez-Cabrera, Heysol C., et al.
Publicado: (2021)

Rationally Designed Anti-CRISPR Nucleic Acid Inhibitors of CRISPR-Cas9
por: Barkau, Christopher L., et al.
Publicado: (2019)

Novel Strategy to Combat Antibiotic Resistance: A Sight into the Combination of CRISPR/Cas9 and Nanoparticles
por: Wan, Fen, et al.
Publicado: (2021)

CRISPR/Cas9-Mediated Efficient Targeted Mutagenesis in Sesame (Sesamum indicum L.)
por: You, Jun, et al.
Publicado: (2022)

Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9
por: Zhang, Xiya, et al.
Publicado: (2016)

Small-molecule inhibitors of proteasome increase CjCas9 protein stability
por: Yaméogo, Pouiré, et al.
Publicado: (2023)

Improving transgene expression and CRISPR‐Cas9 efficiency with molecular engineering‐based molecules
por: Zhan, Hengji, et al.
Publicado: (2020)

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
por: Watters, Kyle E., et al.
Publicado: (2020)

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
por: Thomenius, Michael J., et al.
Publicado: (2018)

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells
por: Estoppey, David, et al.
Publicado: (2017)

Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
por: Neggers, Jasper Edgar, et al.
Publicado: (2018)

What is CRISPR/Cas9?
por: Redman, Melody, et al.
Publicado: (2016)

Advances in CRISPR/Cas9
por: Zhu, Youmin
Publicado: (2022)

CRISPR-assisted transcription activation by phase-separation proteins
por: Liu, Jiaqi, et al.
Publicado: (2023)

CRISPR-Cas9 Mediated Labelling Allows for Single Molecule Imaging and Resolution
por: Khan, Abdullah O., et al.
Publicado: (2017)

Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
por: Zhang, Song, et al.
Publicado: (2021)

The Advance of CRISPR-Cas9-Based and NIR/CRISPR-Cas9-Based Imaging System
por: Qiao, Huanhuan, et al.
Publicado: (2021)

Proxies of CRISPR/Cas9 Activity To Aid in the Identification of Mutagenized Arabidopsis Plants
por: Li, Renyu, et al.
Publicado: (2020)

CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production in Myxococcus xanthus
por: Peng, Ran, et al.
Publicado: (2018)

Identification of genomic sites for CRISPR/Cas9-based genome editing in the Vitis vinifera genome
por: Wang, Yi, et al.
Publicado: (2016)

The effect of histone deacetylase inhibitors on the efficiency of the CRISPR/Cas9 system
por: Björnson, Ymer, et al.
Publicado: (2023)

Application of CRISPR/Cas9 Technology to HBV
por: Lin, Guigao, et al.
Publicado: (2015)

Current trends of clinical trials involving CRISPR/Cas systems
por: Zhang, Songyang, et al.
Publicado: (2023)

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells
por: Kim, Hyeung, et al.
Publicado: (2017)

CRISPR/Cas9 therapeutics: progress and prospects
por: Li, Tianxiang, et al.
Publicado: (2023)

CRISPR/Cas9-based coronal nanostructures for targeted mitochondria single molecule imaging
por: Zhao, Xuan, et al.
Publicado: (2022)

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase
por: Zhou, Zhifen, et al.
Publicado: (2022)

Application of CRISPR/Cas9 for biomedical discoveries
por: Riordan, Sean M., et al.
Publicado: (2015)

CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila
por: Xue, Zhaoyu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jb0gk1rp50cdp32s2m1hjhqd9g