Prostate Cancer Cells Are Sensitive to Lysosomotropic Agent Siramesine through Generation Reactive Oxygen Species and in Combination with Tyrosine Kinase Inhibitors

SIMPLE SUMMARY: Advanced prostate cancer is often drug resistant and requires new treatment strategies. Lysosomoptropic agents selectively target lysosomes in cancer cells leading to cell death. We found that the lysosome-targeted drug, siramesine, induced cell death in prostate cancer cells lines t...

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Detalles Bibliográficos
Autores principales: Garcia, Emily A., Bhatti, Ilsa, Henson, Elizabeth S., Gibson, Spencer B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688505/
https://www.ncbi.nlm.nih.gov/pubmed/36428570
http://dx.doi.org/10.3390/cancers14225478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688505/
https://www.ncbi.nlm.nih.gov/pubmed/36428570
http://dx.doi.org/10.3390/cancers14225478

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