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Prostate Cancer Cells Are Sensitive to Lysosomotropic Agent Siramesine through Generation Reactive Oxygen Species and in Combination with Tyrosine Kinase Inhibitors
SIMPLE SUMMARY: Advanced prostate cancer is often drug resistant and requires new treatment strategies. Lysosomoptropic agents selectively target lysosomes in cancer cells leading to cell death. We found that the lysosome-targeted drug, siramesine, induced cell death in prostate cancer cells lines t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688505/ https://www.ncbi.nlm.nih.gov/pubmed/36428570 http://dx.doi.org/10.3390/cancers14225478 |