Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures

Dysfunctional autophagy is linked to neuronal damage in ischemia/reperfusion injury. The Ras-related protein 7 (Rab7), a member of the Rab family of small GTPases, appears crucial for the progression of the autophagic flux, and its activity is strictly interconnected with the histone deacetylase Sil...

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Detalles Bibliográficos
Autores principales: Luchetti, Francesca, Nasoni, Maria G., Burattini, Sabrina, Mohammadi, Atefeh, Pagliarini, Marica, Canonico, Barbara, Ambrogini, Patrizia, Balduini, Walter, Reiter, Russel J., Carloni, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688641/
https://www.ncbi.nlm.nih.gov/pubmed/36429130
http://dx.doi.org/10.3390/cells11223701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688641/
https://www.ncbi.nlm.nih.gov/pubmed/36429130
http://dx.doi.org/10.3390/cells11223701

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