RNA Polymerase I Is Uniquely Vulnerable to the Small-Molecule Inhibitor BMH-21

SIMPLE SUMMARY: Cancer cells upregulate RNA polymerase I (Pol I) activity to increase ribosome abundance in support of rapid cell growth and proliferation. During the last decade, Pol I has emerged as a promising anti-cancer target. Eukaryotes express three closely related RNA polymerases (Pols I, I...

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Detalles Bibliográficos
Autores principales: Jacobs, Ruth Q., Fuller, Kaila B., Cooper, Stephanie L., Carter, Zachariah I., Laiho, Marikki, Lucius, Aaron L., Schneider, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688676/
https://www.ncbi.nlm.nih.gov/pubmed/36428638
http://dx.doi.org/10.3390/cancers14225544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688676/
https://www.ncbi.nlm.nih.gov/pubmed/36428638
http://dx.doi.org/10.3390/cancers14225544

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