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RNA Polymerase I Is Uniquely Vulnerable to the Small-Molecule Inhibitor BMH-21

SIMPLE SUMMARY: Cancer cells upregulate RNA polymerase I (Pol I) activity to increase ribosome abundance in support of rapid cell growth and proliferation. During the last decade, Pol I has emerged as a promising anti-cancer target. Eukaryotes express three closely related RNA polymerases (Pols I, I...

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Detalles Bibliográficos
Autores principales:	Jacobs, Ruth Q., Fuller, Kaila B., Cooper, Stephanie L., Carter, Zachariah I., Laiho, Marikki, Lucius, Aaron L., Schneider, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688676/ https://www.ncbi.nlm.nih.gov/pubmed/36428638 http://dx.doi.org/10.3390/cancers14225544

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