Cargando…

o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells

Human mesenchymal stem cell (hMSC) and extracellular vesicle (EV) therapy is a promising treatment for discogenic low back pain (LBP). Although promising, major obstacles remain to be overcome. Cellular senescence reduces self-renewal and multipotent potentials, and the senescence-associated secreto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Li, Sheng, Kai, Mannarino, Matthew, Jarzem, Peter, Cherif, Hosni, Haglund, Lisbet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688801/ https://www.ncbi.nlm.nih.gov/pubmed/36429018 http://dx.doi.org/10.3390/cells11223589

Ejemplares similares

Toll-like receptor 2 induced senescence in intervertebral disc cells of patients with back pain can be attenuated by o-vanillin
por: Mannarino, Matthew, et al.
Publicado: (2021)

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degeneration
por: Cherif, Hosni, et al.
Publicado: (2022)

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro
por: Cherif, Hosni, et al.
Publicado: (2019)

Senotherapeutic drugs for human intervertebral disc degeneration and low back pain
por: Cherif, Hosni, et al.
Publicado: (2020)

Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs
por: Mannarino, Matthew, et al.
Publicado: (2023)

Maintenance of cell viability in axially loaded intervertebral disc organ culture
por: Awwad, Waleed, et al.
Publicado: (2011)

Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors
por: Krock, Emerson, et al.
Publicado: (2014)

Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration
por: Cui, Shangbin, et al.
Publicado: (2022)

Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration
por: Wu, Xinjie, et al.
Publicado: (2022)

Development of a whole disc organ culture system to study human intervertebral disc
por: Parolin, M., et al.
Publicado: (2010)

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Immunomodulatory Effects and Potential Applications in Intervertebral Disc Degeneration
por: Hu, Shaojun, et al.
Publicado: (2022)

Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response
por: Wangler, Sebastian, et al.
Publicado: (2019)

High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain
por: Gawri, Rahul, et al.
Publicado: (2014)

Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis
por: Wangler, Sebastian, et al.
Publicado: (2021)

Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration
por: Yu, Xiao-Jun, et al.
Publicado: (2022)

Vanillin-based functionalization strategy to construct multifunctional microspheres for treating inflammation and regenerating intervertebral disc
por: Zhu, Zhuang, et al.
Publicado: (2023)

Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc
por: Piazza, Nathan, et al.
Publicado: (2020)

Toll-like Receptor Activation Induces Degeneration of Human Intervertebral Discs
por: Krock, Emerson, et al.
Publicado: (2017)

circ_0072464 Shuttled by Bone Mesenchymal Stem Cell-Secreted Extracellular Vesicles Inhibits Nucleus Pulposus Cell Ferroptosis to Relieve Intervertebral Disc Degeneration
por: Yu, Xiaojun, et al.
Publicado: (2022)

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes
por: Minogue, Ben M, et al.
Publicado: (2010)

Mesenchymal stem cell extracellular vesicles-derived microRNA-194-5p delays the development of intervertebral disc degeneration by targeting TRAF6
por: Sun, Zhongyi, et al.
Publicado: (2022)

A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration
por: Ohnishi, Takashi, et al.
Publicado: (2023)

Selective cargo sorting in stem cell‐derived small extracellular vesicles: impact on therapeutic efficacy for intervertebral disc degeneration
por: Liao, Zhiwei, et al.
Publicado: (2023)

Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain
por: Wuertz, Karin, et al.
Publicado: (2013)

Mesenchymal Stem Cell for Prevention and Management of Intervertebral Disc Degeneration
por: Longo, Umile Giuseppe, et al.
Publicado: (2012)

Cryopreserved Mesenchymal Stem Cells Stimulate Regeneration in an Intervertebral Disc
por: Volkova, Nataliia, et al.
Publicado: (2015)

The Influence of Intervertebral Disc Microenvironment on the Biological Behavior of Engrafted Mesenchymal Stem Cells
por: Zhang, Jing, et al.
Publicado: (2022)

Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction
por: Dai, Zhanqiu, et al.
Publicado: (2022)

Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration
por: Huang, Huagui, et al.
Publicado: (2023)

The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc
por: Croft, Andreas S., et al.
Publicado: (2021)

Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review
por: Bhujel, Basanta, et al.
Publicado: (2022)

miR-31 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviates Intervertebral Disc Degeneration by Inhibiting NFAT5 and Upregulating the Wnt/β-Catenin Pathway
por: Wang, Baodong, et al.
Publicado: (2022)

Changes in the Molecular Phenotype of Nucleus Pulposus Cells with Intervertebral Disc Aging
por: Tang, Xinyan, et al.
Publicado: (2012)

A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration
por: Shu, Cindy C., et al.
Publicado: (2017)

Intervertebral Disc-Derived Stem/Progenitor Cells as a Promising Cell Source for Intervertebral Disc Regeneration
por: Hu, Binwu, et al.
Publicado: (2018)

Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc
por: Liang, Chengzhen, et al.
Publicado: (2012)

Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation
por: Turner, Sarah A., et al.
Publicado: (2016)

Intervertebral disc cell- and hydrogel-supported and spontaneous intervertebral disc repair in nucleotomized sheep
por: Benz, Karin, et al.
Publicado: (2012)

Intervertebral Disc Stem/Progenitor Cells: A Promising “Seed” for Intervertebral Disc Regeneration
por: Du, Yuxiang, et al.
Publicado: (2021)

Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling
por: Pereira, Catarina Leite, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t2grof1f2pdcgna5tlr5jtlt3b