Distinct Dynamics of Migratory Response to PD-1 and CTLA-4 Blockade Reveals New Mechanistic Insights for Potential T-Cell Reinvigoration following Immune Checkpoint Blockade

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), two clinically relevant targets for the immunotherapy of cancer, are negative regulators of T-cell activation and migration. Optimizing the therapeutic response to CTLA-4 and PD-1 blockade calls for a mo...

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Detalles Bibliográficos
Autores principales: Safaeifard, Fateme, Goliaei, Bahram, Aref, Amir R., Foroughmand-Araabi, Mohammad-Hadi, Goliaei, Sama, Lorch, Jochen, Jenkins, Russell W., Barbie, David A., Shariatpanahi, Seyed Peyman, Rüegg, Curzio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688893/
https://www.ncbi.nlm.nih.gov/pubmed/36428963
http://dx.doi.org/10.3390/cells11223534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688893/
https://www.ncbi.nlm.nih.gov/pubmed/36428963
http://dx.doi.org/10.3390/cells11223534

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