The Complex Dynamic of Phase I Drug Metabolism in the Early Stages of Doxorubicin Resistance in Breast Cancer Cells

The altered activity of drug metabolism enzymes (DMEs) is a hallmark of chemotherapy resistance. Cytochrome P450s (CYPs), mainly CYP3A4, and several oxidoreductases are responsible for Phase I metabolism of doxorubicin (DOX), an anthracycline widely used in breast cancer (BC) treatment. This study a...

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Detalles Bibliográficos
Autores principales: Barata, Isabel S., Gomes, Bruno C., Rodrigues, António S., Rueff, José, Kranendonk, Michel, Esteves, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689592/
https://www.ncbi.nlm.nih.gov/pubmed/36360213
http://dx.doi.org/10.3390/genes13111977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689592/
https://www.ncbi.nlm.nih.gov/pubmed/36360213
http://dx.doi.org/10.3390/genes13111977

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