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Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance
Background: The exposure patterns of respirable crystalline silica based on environmental records, as well as the link to different diseases, are not well described. Aims and objectives: In this study, we evaluated the risk for various diseases in relation to occupational silica exposure, including...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690112/ https://www.ncbi.nlm.nih.gov/pubmed/36429737 http://dx.doi.org/10.3390/ijerph192215010 |
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author | Raanan, Rachel Zack, Oren Ruben, Maya Perluk, Idan Moshe, Shlomo |
author_facet | Raanan, Rachel Zack, Oren Ruben, Maya Perluk, Idan Moshe, Shlomo |
author_sort | Raanan, Rachel |
collection | PubMed |
description | Background: The exposure patterns of respirable crystalline silica based on environmental records, as well as the link to different diseases, are not well described. Aims and objectives: In this study, we evaluated the risk for various diseases in relation to occupational silica exposure, including Silicosis, pulmonary tuberculosis (TB), Autoimmune disorders (AIDs) and Renal diseases. Methods: We assessed the relationship between silica exposure and the rate of various diseases such as silicosis, pulmonary TB, AIDs and renal diseases in a cross-sectional study. We reviewed the medical records and exposure level of workers exposed to silica during the past two decades. Results: 261 workers were included in the study, total duration of exposure 15.6 years (±SD 8.74); 42.15% of them were employed in the artificial marble industry and 29.5% in manufacturing and construction industries. The average yearly silica exposure levels were 0.23 mg/m(3) (±0.34). The average cumulative silica concentration was 3.59 mg/m(3)/y (±4.80). We found 25 (9.58%) incident cases of silicosis, 10 cases of chronic obstructive pulmonary disease (COPD) and emphysema (3.83%), six cases of several AIDs (2.30%), five cases of pulmonary TB (1.92%), three cases of renal diseases (1.15%), two cases of sarcoidosis (0.77%) and no lung cancer cases. When compared to studies with the same endpoint we found excess risk of silicosis (RR = 2.67/0.13 = 20.5, 95% CI 9.85 to 42.86)), pulmonary TB (RR = 30.70, CI 3.43–274.49, p = 0.002) and AIDs (RR = 2.87, 95% CI = 1.27 to 6.48 p = 0.01). Conclusions: Silica exposure was a significant risk factor for silicosis, pulmonary TB and AIDs. Our findings are important given persistent worldwide silica-related epidemics in low and high-income countries. |
format | Online Article Text |
id | pubmed-9690112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96901122022-11-25 Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance Raanan, Rachel Zack, Oren Ruben, Maya Perluk, Idan Moshe, Shlomo Int J Environ Res Public Health Article Background: The exposure patterns of respirable crystalline silica based on environmental records, as well as the link to different diseases, are not well described. Aims and objectives: In this study, we evaluated the risk for various diseases in relation to occupational silica exposure, including Silicosis, pulmonary tuberculosis (TB), Autoimmune disorders (AIDs) and Renal diseases. Methods: We assessed the relationship between silica exposure and the rate of various diseases such as silicosis, pulmonary TB, AIDs and renal diseases in a cross-sectional study. We reviewed the medical records and exposure level of workers exposed to silica during the past two decades. Results: 261 workers were included in the study, total duration of exposure 15.6 years (±SD 8.74); 42.15% of them were employed in the artificial marble industry and 29.5% in manufacturing and construction industries. The average yearly silica exposure levels were 0.23 mg/m(3) (±0.34). The average cumulative silica concentration was 3.59 mg/m(3)/y (±4.80). We found 25 (9.58%) incident cases of silicosis, 10 cases of chronic obstructive pulmonary disease (COPD) and emphysema (3.83%), six cases of several AIDs (2.30%), five cases of pulmonary TB (1.92%), three cases of renal diseases (1.15%), two cases of sarcoidosis (0.77%) and no lung cancer cases. When compared to studies with the same endpoint we found excess risk of silicosis (RR = 2.67/0.13 = 20.5, 95% CI 9.85 to 42.86)), pulmonary TB (RR = 30.70, CI 3.43–274.49, p = 0.002) and AIDs (RR = 2.87, 95% CI = 1.27 to 6.48 p = 0.01). Conclusions: Silica exposure was a significant risk factor for silicosis, pulmonary TB and AIDs. Our findings are important given persistent worldwide silica-related epidemics in low and high-income countries. MDPI 2022-11-15 /pmc/articles/PMC9690112/ /pubmed/36429737 http://dx.doi.org/10.3390/ijerph192215010 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Raanan, Rachel Zack, Oren Ruben, Maya Perluk, Idan Moshe, Shlomo Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance |
title | Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance |
title_full | Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance |
title_fullStr | Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance |
title_full_unstemmed | Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance |
title_short | Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance |
title_sort | occupational silica exposure and dose–response for related disorders—silicosis, pulmonary tb, aids and renal diseases: results of a 15-year israeli surveillance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690112/ https://www.ncbi.nlm.nih.gov/pubmed/36429737 http://dx.doi.org/10.3390/ijerph192215010 |
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