Continuous Flow Processes as an Enabling Tool for the Synthesis of Constrained Pseudopeptidic Macrocycles

[Image: see text] Herein we report our efforts to develop a continuous flow methodology for the efficient preparation of pseudopeptidic macrocyclic compounds containing the hexahydropyrrolo-[3,4-f]-isoindolocyclophane scaffold and involving four coupled substitution reactions in the macrocyclization...

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Detalles Bibliográficos
Autores principales: Esteve, Ferran, Porcar, Raul, Luis, Santiago V., Altava, Belen, García-Verdugo, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690154/
https://www.ncbi.nlm.nih.gov/pubmed/35166527
http://dx.doi.org/10.1021/acs.joc.1c03081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690154/
https://www.ncbi.nlm.nih.gov/pubmed/35166527
http://dx.doi.org/10.1021/acs.joc.1c03081

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