Modelling SARS-CoV-2 spike-protein mutation effects on ACE2 binding

The binding affinity of the SARS-CoV-2 spike (S)-protein to the human membrane protein ACE2 is critical for virus function. Computational structure-based screening of new S-protein mutations for ACE2 binding lends promise to rationalize virus function directly from protein structure and ideally aid...

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Detalles Bibliográficos
Autores principales: Thakur, Shivani, Verma, Rajaneesh Kumar, Kepp, Kasper Planeta, Mehra, Rukmankesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690204/
https://www.ncbi.nlm.nih.gov/pubmed/36481587
http://dx.doi.org/10.1016/j.jmgm.2022.108379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690204/
https://www.ncbi.nlm.nih.gov/pubmed/36481587
http://dx.doi.org/10.1016/j.jmgm.2022.108379

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