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Modelling SARS-CoV-2 spike-protein mutation effects on ACE2 binding
The binding affinity of the SARS-CoV-2 spike (S)-protein to the human membrane protein ACE2 is critical for virus function. Computational structure-based screening of new S-protein mutations for ACE2 binding lends promise to rationalize virus function directly from protein structure and ideally aid...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690204/ https://www.ncbi.nlm.nih.gov/pubmed/36481587 http://dx.doi.org/10.1016/j.jmgm.2022.108379 |