XLRS Rat with Rs1(-/Y) Exon-1-Del Shows Failure of Early Postnatal Outer Retina Development

We generated a Long Evans transgenic rat with targeted deletion of the whole Rs1 exon-1 and evaluated the pathological retinal phenotype of this Rs1(-/Y) rat model of X-linked retinoschisis (XLRS). The Rs1(−/Y) rat exhibited very early onset and rapidly progressive photoreceptor degeneration. The ou...

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Detalles Bibliográficos
Autores principales: Ye, Eun-Ah, Zeng, Yong, Thomas, Serafina, Sun, Ning, Smit-McBride, Zeljka, Sieving, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690472/
https://www.ncbi.nlm.nih.gov/pubmed/36360232
http://dx.doi.org/10.3390/genes13111995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690472/
https://www.ncbi.nlm.nih.gov/pubmed/36360232
http://dx.doi.org/10.3390/genes13111995

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