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XLRS Rat with Rs1(-/Y) Exon-1-Del Shows Failure of Early Postnatal Outer Retina Development
We generated a Long Evans transgenic rat with targeted deletion of the whole Rs1 exon-1 and evaluated the pathological retinal phenotype of this Rs1(-/Y) rat model of X-linked retinoschisis (XLRS). The Rs1(−/Y) rat exhibited very early onset and rapidly progressive photoreceptor degeneration. The ou...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690472/ https://www.ncbi.nlm.nih.gov/pubmed/36360232 http://dx.doi.org/10.3390/genes13111995 |