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Real-World Outcomes of Systemic Therapy in Japanese Patients with Cancer (Tokushukai REAl-World Data Project: TREAD): Study Protocol for a Nationwide Cohort Study

Cohort studies using large-scale databases have become increasingly important in recent years. The Tokushukai Medical Group is a leading medical group in Japan that includes 71 general hospitals nationwide from Hokkaido to Okinawa, with a total of 18,000 beds, and a unified electronic medical record...

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Autores principales: Shimoyama, Rai, Imamura, Yoshinori, Uryu, Kiyoaki, Mase, Takahiro, Fujimura, Yoshiaki, Hayashi, Maki, Ohtaki, Megu, Ohtani, Keiko, Shinozaki, Nobuaki, Minami, Hironobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690553/
https://www.ncbi.nlm.nih.gov/pubmed/36360487
http://dx.doi.org/10.3390/healthcare10112146
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author Shimoyama, Rai
Imamura, Yoshinori
Uryu, Kiyoaki
Mase, Takahiro
Fujimura, Yoshiaki
Hayashi, Maki
Ohtaki, Megu
Ohtani, Keiko
Shinozaki, Nobuaki
Minami, Hironobu
author_facet Shimoyama, Rai
Imamura, Yoshinori
Uryu, Kiyoaki
Mase, Takahiro
Fujimura, Yoshiaki
Hayashi, Maki
Ohtaki, Megu
Ohtani, Keiko
Shinozaki, Nobuaki
Minami, Hironobu
author_sort Shimoyama, Rai
collection PubMed
description Cohort studies using large-scale databases have become increasingly important in recent years. The Tokushukai Medical Group is a leading medical group in Japan that includes 71 general hospitals nationwide from Hokkaido to Okinawa, with a total of 18,000 beds, and a unified electronic medical record system. This retrospective cohort study aims to evaluate the real-world outcomes of systemic therapy for Japanese patients with cancer using this merit of scale. All adult patients with cancer who received systemic therapy using a centrally registered chemotherapy protocol system at 46 hospitals from April 2010 to March 2020 will be identified (~48,850 patients). Key exclusion criteria include active double cancer and inadequate data extraction. Data will be obtained through electronic medical records, diagnosis procedure combination data, medical prescription data, and the national cancer registration system that includes sociodemographic variables, diagnostic and laboratory tests, concomitant drug prescriptions, cost, and overall survival. Kaplan–Meier estimates will be calculated for time-to-event analyses. Stratified/conventional Cox proportional hazards regression analyses will be conducted to examine the relationships between overall survival and related factors. Our findings provide important insights for future research directions, policy initiatives, medical guidelines, and clinical decision-making.
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spelling pubmed-96905532022-11-25 Real-World Outcomes of Systemic Therapy in Japanese Patients with Cancer (Tokushukai REAl-World Data Project: TREAD): Study Protocol for a Nationwide Cohort Study Shimoyama, Rai Imamura, Yoshinori Uryu, Kiyoaki Mase, Takahiro Fujimura, Yoshiaki Hayashi, Maki Ohtaki, Megu Ohtani, Keiko Shinozaki, Nobuaki Minami, Hironobu Healthcare (Basel) Study Protocol Cohort studies using large-scale databases have become increasingly important in recent years. The Tokushukai Medical Group is a leading medical group in Japan that includes 71 general hospitals nationwide from Hokkaido to Okinawa, with a total of 18,000 beds, and a unified electronic medical record system. This retrospective cohort study aims to evaluate the real-world outcomes of systemic therapy for Japanese patients with cancer using this merit of scale. All adult patients with cancer who received systemic therapy using a centrally registered chemotherapy protocol system at 46 hospitals from April 2010 to March 2020 will be identified (~48,850 patients). Key exclusion criteria include active double cancer and inadequate data extraction. Data will be obtained through electronic medical records, diagnosis procedure combination data, medical prescription data, and the national cancer registration system that includes sociodemographic variables, diagnostic and laboratory tests, concomitant drug prescriptions, cost, and overall survival. Kaplan–Meier estimates will be calculated for time-to-event analyses. Stratified/conventional Cox proportional hazards regression analyses will be conducted to examine the relationships between overall survival and related factors. Our findings provide important insights for future research directions, policy initiatives, medical guidelines, and clinical decision-making. MDPI 2022-10-28 /pmc/articles/PMC9690553/ /pubmed/36360487 http://dx.doi.org/10.3390/healthcare10112146 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Study Protocol
Shimoyama, Rai
Imamura, Yoshinori
Uryu, Kiyoaki
Mase, Takahiro
Fujimura, Yoshiaki
Hayashi, Maki
Ohtaki, Megu
Ohtani, Keiko
Shinozaki, Nobuaki
Minami, Hironobu
Real-World Outcomes of Systemic Therapy in Japanese Patients with Cancer (Tokushukai REAl-World Data Project: TREAD): Study Protocol for a Nationwide Cohort Study
title Real-World Outcomes of Systemic Therapy in Japanese Patients with Cancer (Tokushukai REAl-World Data Project: TREAD): Study Protocol for a Nationwide Cohort Study
title_full Real-World Outcomes of Systemic Therapy in Japanese Patients with Cancer (Tokushukai REAl-World Data Project: TREAD): Study Protocol for a Nationwide Cohort Study
title_fullStr Real-World Outcomes of Systemic Therapy in Japanese Patients with Cancer (Tokushukai REAl-World Data Project: TREAD): Study Protocol for a Nationwide Cohort Study
title_full_unstemmed Real-World Outcomes of Systemic Therapy in Japanese Patients with Cancer (Tokushukai REAl-World Data Project: TREAD): Study Protocol for a Nationwide Cohort Study
title_short Real-World Outcomes of Systemic Therapy in Japanese Patients with Cancer (Tokushukai REAl-World Data Project: TREAD): Study Protocol for a Nationwide Cohort Study
title_sort real-world outcomes of systemic therapy in japanese patients with cancer (tokushukai real-world data project: tread): study protocol for a nationwide cohort study
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690553/
https://www.ncbi.nlm.nih.gov/pubmed/36360487
http://dx.doi.org/10.3390/healthcare10112146
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