Cell-Specific Transport and Thyroid Hormone Receptor Isoform Selectivity Account for Hepatocyte-Targeted Thyromimetic Action of MGL-3196

Thyroid hormones (THs) and TH receptor-beta (TRβ) reduce hepatic triglycerides, indicating a therapeutic potential for TH analogs in liver steatosis. To avoid adverse extrahepatic, especially TRα-mediated effects such as tachycardia and bone loss, TH analogs with combined TRβ and hepatocyte specific...

Descripción completa

Detalles Bibliográficos
Autores principales: Hönes, Georg Sebastian, Sivakumar, Ramona Gowry, Hoppe, Christoph, König, Jörg, Führer, Dagmar, Moeller, Lars Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691000/
https://www.ncbi.nlm.nih.gov/pubmed/36430194
http://dx.doi.org/10.3390/ijms232213714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691000/
https://www.ncbi.nlm.nih.gov/pubmed/36430194
http://dx.doi.org/10.3390/ijms232213714

Ejemplares similares