Cargando…

Cell-Specific Transport and Thyroid Hormone Receptor Isoform Selectivity Account for Hepatocyte-Targeted Thyromimetic Action of MGL-3196

Thyroid hormones (THs) and TH receptor-beta (TRβ) reduce hepatic triglycerides, indicating a therapeutic potential for TH analogs in liver steatosis. To avoid adverse extrahepatic, especially TRα-mediated effects such as tachycardia and bone loss, TH analogs with combined TRβ and hepatocyte specific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hönes, Georg Sebastian, Sivakumar, Ramona Gowry, Hoppe, Christoph, König, Jörg, Führer, Dagmar, Moeller, Lars Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691000/ https://www.ncbi.nlm.nih.gov/pubmed/36430194 http://dx.doi.org/10.3390/ijms232213714

Ejemplares similares

Thyroid Hormones, Thyromimetics and Their Metabolites in the Treatment of Liver Disease
por: Kowalik, Marta A., et al.
Publicado: (2018)

Thyroid Hormones and Thyromimetics: A New Approach to Nonalcoholic Steatohepatitis?
por: Sinha, Rohit A., et al.
Publicado: (2020)

Protective Effects of Thyroid Hormone Deprivation on Progression of Maladaptive Cardiac Hypertrophy and Heart Failure
por: Kerp, Helena, et al.
Publicado: (2021)

Thyromimetics: What does the future hold?
por: Unnikrishnan, A. G., et al.
Publicado: (2012)

Development of Thyroid Hormones and Synthetic Thyromimetics in Non-Alcoholic Fatty Liver Disease
por: Zhao, Man, et al.
Publicado: (2022)

Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics—Role of Canonical Thyroid Hormone Receptor Alpha Signaling
por: Pape, Janina, et al.
Publicado: (2022)

Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis
por: Kim, Bokyung, et al.
Publicado: (2021)

Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice
por: Rakov, Helena, et al.
Publicado: (2017)

Sex-specific phenotypes of hyperthyroidism and hypothyroidism in mice
por: Rakov, Helena, et al.
Publicado: (2016)

The Liver-Selective Thyromimetic T-0681 Influences Reverse Cholesterol Transport and Atherosclerosis Development in Mice
por: Tancevski, Ivan, et al.
Publicado: (2010)

Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity
por: Miertzschke, Mandy, et al.
Publicado: (2011)

MglC, a Paralog of Myxococcus xanthus GTPase-Activating Protein MglB, Plays a Divergent Role in Motility Regulation
por: McLoon, Anna L., et al.
Publicado: (2016)

Structural characterization of Myxococcus xanthus MglC, a component of the polarity control system, and its interactions with its paralog MglB
por: Kapoor, Srajan, et al.
Publicado: (2021)

MAFG-AS1 aggravates the progression of pancreatic cancer by sponging miR-3196 to boost NFIX
por: Ye, Liqing, et al.
Publicado: (2020)

miR-3196 acts as a Tumor Suppressor and Predicts Survival Outcomes in Patients With Gastric Cancer
por: Chen, Guo, et al.
Publicado: (2020)

A Response Regulator Interfaces between the Frz Chemosensory System and the MglA/MglB GTPase/GAP Module to Regulate Polarity in Myxococcus xanthus
por: Keilberg, Daniela, et al.
Publicado: (2012)

MglB Fills a GAP in Bacterial Polarity and Motility
por: Sedwick, Caitlin
Publicado: (2010)

MGL Receptor and Immunity: When the Ligand Can Make the Difference
por: Zizzari, Ilaria Grazia, et al.
Publicado: (2015)

Erratum to “Assembly and disassembly of the ESCRT-III membrane scission complex” [FEBS Lett. 585 (2011) 3191–3196]
por: Adell, Manuel Alonso Y, et al.
Publicado: (2012)

3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement
por: Nwankwo, Vesta, et al.
Publicado: (2019)

Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis
por: Caddeo, Andrea, et al.
Publicado: (2023)

The role of MglA for adaptation to oxidative stress of Francisella tularensis LVS
por: Honn, Marie, et al.
Publicado: (2012)

MglA/SspA Complex Interactions Are Modulated by Inorganic Polyphosphate
por: Wrench, Algevis P., et al.
Publicado: (2013)

Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells
por: Pirro, Martina, et al.
Publicado: (2018)

Functional Characterization of Olfactory Receptors in the Thyroid Gland
por: Weidinger, Daniel, et al.
Publicado: (2021)

A Comparison of the Quality of Hypertension Management in Primary Care Between Shanghai and Shenzhen: A Cohort Study of 3196 Patients
por: Li, Haitao, et al.
Publicado: (2015)

MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA
por: Xu, Chengshan, et al.
Publicado: (2016)

The EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population
por: Zhang, Li, et al.
Publicado: (2021)

MGL2(+) Dermal Dendritic Cells Are Sufficient to Initiate Contact Hypersensitivity In Vivo
por: Kumamoto, Yosuke, et al.
Publicado: (2009)

Effects of site-directed mutagenesis of mglA on motility and swarming of Myxococcus xanthus
por: Fremgen, Sarah A, et al.
Publicado: (2010)

Translation and validation of the Arabic version of the Morisky, Green and Levine (MGL) adherence scale
por: Awwad, Oriana, et al.
Publicado: (2022)

The EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population [Corrigendum]
Publicado: (2021)

Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics
por: Runfola, Massimiliano, et al.
Publicado: (2020)

Maternal Administration of the CNS-Selective Sobetirome Prodrug Sob-AM2 Exerts Thyromimetic Effects in Murine MCT8-Deficient Fetuses
por: Valcárcel-Hernández, Víctor, et al.
Publicado: (2023)

TRα2—An Untuned Second Fiddle or Fine-Tuning Thyroid Hormone Action?
por: Hönes, Georg Sebastian, et al.
Publicado: (2022)

Conferring liver selectivity to a thyromimetic using a novel nanoparticle increases therapeutic efficacy in a diet-induced obesity animal model
por: Wu, Ruiling, et al.
Publicado: (2023)

The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions
por: Zizzari, Ilaria Grazia, et al.
Publicado: (2015)

Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL
por: Scalvini, Laura, et al.
Publicado: (2016)

Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket
por: Grininger, Christoph, et al.
Publicado: (2021)

The interplay of thyroid hormones and the immune system – where we stand and why we need to know about it
por: Wenzek, Christina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7tl4ji2nue0ii5r9qn09tbvam6