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Cell-Specific Transport and Thyroid Hormone Receptor Isoform Selectivity Account for Hepatocyte-Targeted Thyromimetic Action of MGL-3196

Thyroid hormones (THs) and TH receptor-beta (TRβ) reduce hepatic triglycerides, indicating a therapeutic potential for TH analogs in liver steatosis. To avoid adverse extrahepatic, especially TRα-mediated effects such as tachycardia and bone loss, TH analogs with combined TRβ and hepatocyte specific...

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Detalles Bibliográficos
Autores principales:	Hönes, Georg Sebastian, Sivakumar, Ramona Gowry, Hoppe, Christoph, König, Jörg, Führer, Dagmar, Moeller, Lars Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691000/ https://www.ncbi.nlm.nih.gov/pubmed/36430194 http://dx.doi.org/10.3390/ijms232213714

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