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Reevaluation of Piezo1 as a gut RNA sensor

Piezo1 is a stretch-gated ion channel required for mechanosensation in many organ systems. Recent findings point to a new role for Piezo1 in the gut, suggesting that it is a sensor of microbial single-stranded RNA (ssRNA) rather than mechanical force. If true, this would redefine the scope of Piezo...

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Detalles Bibliográficos
Autores principales: Nickolls, Alec R, O'Brien, Gabrielle S, Shnayder, Sarah, Zhang, Yunxiao, Nagel, Maximilian, Patapoutian, Ardem, Chesler, Alexander T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691018/
https://www.ncbi.nlm.nih.gov/pubmed/36382883
http://dx.doi.org/10.7554/eLife.83346