Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin

The auto-inhibited, super-relaxed (SRX) state of cardiac myosin is thought to be crucial for regulating contraction, relaxation, and energy conservation in the heart. We used single ATP turnover experiments to demonstrate that a dilated cardiomyopathy (DCM) mutation (E525K) in human beta-cardiac myo...

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Detalles Bibliográficos
Autores principales: Rasicci, David V, Tiwari, Prince, Bodt, Skylar ML, Desetty, Rohini, Sadler, Fredrik R, Sivaramakrishnan, Sivaraj, Craig, Roger, Yengo, Christopher M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691020/
https://www.ncbi.nlm.nih.gov/pubmed/36422472
http://dx.doi.org/10.7554/eLife.77415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691020/
https://www.ncbi.nlm.nih.gov/pubmed/36422472
http://dx.doi.org/10.7554/eLife.77415

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