SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans

SNPs in ABCA7 confer the largest genetic risk for Alzheimer’s Disease (AD) in African Americans (AA) after APOE ε4. However, the relationship between ABCA7 and cognitive function has not been thoroughly examined. We investigated the effects of five known AD risk SNPs and 72 CpGs in ABCA7, as well as...

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Detalles Bibliográficos
Autores principales: Chaar, Dima L., Nguyen, Kim, Wang, Yi-Zhe, Ratliff, Scott M., Mosley, Thomas H., Kardia, Sharon L. R., Smith, Jennifer A., Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691156/
https://www.ncbi.nlm.nih.gov/pubmed/36421824
http://dx.doi.org/10.3390/genes13112150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691156/
https://www.ncbi.nlm.nih.gov/pubmed/36421824
http://dx.doi.org/10.3390/genes13112150

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