BHF177 Suppresses Diabetic Neuropathic Pain by Blocking PKC/CaMKII/ERK1/2/CREB Signaling Pathway through Activating GABA(B) Receptor

The gamma-aminobutyric acid type B (GABA(B)) receptor may participate in the development of diabetic neuropathic pain (DNP). BHF177 serves as a positive allosteric modulator of the GABA(B) receptor. In the current study, we sought to study the role of the BHF177-GABA(B) receptor in DNP and its under...

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Detalles Bibliográficos
Autores principales: Liu, Boyu, Guan, Fengxi, Zhao, Jiapeng, Niu, Yao, Jiang, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691330/
https://www.ncbi.nlm.nih.gov/pubmed/36439691
http://dx.doi.org/10.1155/2022/4661519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691330/
https://www.ncbi.nlm.nih.gov/pubmed/36439691
http://dx.doi.org/10.1155/2022/4661519

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