Cargando…

BHF177 Suppresses Diabetic Neuropathic Pain by Blocking PKC/CaMKII/ERK1/2/CREB Signaling Pathway through Activating GABA(B) Receptor

The gamma-aminobutyric acid type B (GABA(B)) receptor may participate in the development of diabetic neuropathic pain (DNP). BHF177 serves as a positive allosteric modulator of the GABA(B) receptor. In the current study, we sought to study the role of the BHF177-GABA(B) receptor in DNP and its under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Boyu, Guan, Fengxi, Zhao, Jiapeng, Niu, Yao, Jiang, Hongbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691330/ https://www.ncbi.nlm.nih.gov/pubmed/36439691 http://dx.doi.org/10.1155/2022/4661519

Ejemplares similares

The Role of CaMKII and ERK Signaling in Addiction
por: Jia, Wenbin, et al.
Publicado: (2021)

Tilianin Ameliorates Cognitive Dysfunction and Neuronal Damage in Rats with Vascular Dementia via p-CaMKII/ERK/CREB and ox-CaMKII-Dependent MAPK/NF-κB Pathways
por: Jiang, Hailun, et al.
Publicado: (2021)

HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons
por: Liu, Xiaoyu, et al.
Publicado: (2018)

The κ-Opioid Receptor Agonist U50488H Ameliorates Neuropathic Pain Through the Ca(2+)/CaMKII/CREB Pathway in Rats
por: Zhang, Xiao-Min, et al.
Publicado: (2022)

CaMKII points the way
por: Leslie, Mitch
Publicado: (2012)

CaMKII in Cardiometabolic Disease
por: Ozcan, Lale, et al.
Publicado: (2014)

Synaptic memory and CaMKII
por: Nicoll, Roger A., et al.
Publicado: (2023)

Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats
por: Islam, Rafiad, et al.
Publicado: (2019)

Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes
por: Koyani, Chintan N., et al.
Publicado: (2018)

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy
por: Cipolletta, Ersilia, et al.
Publicado: (2015)

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation
por: Rellos, Peter, et al.
Publicado: (2010)

Glucocorticoid receptors recruit the CaMKIIα, BDNF–CREB pathways to mediate memory consolidation
por: Chen, Dillon Y., et al.
Publicado: (2012)

Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing
por: Arzt, Michael, et al.
Publicado: (2022)

NMDA receptor-mediated CaMKII/ERK activation contributes to renal fibrosis
por: Zhou, Jingyi, et al.
Publicado: (2020)

Mechanisms of CaMKII Activation in the Heart
por: Erickson, Jeffrey R.
Publicado: (2014)

The emerging role of CaMKII in cancer
por: Wang, Yan-yang, et al.
Publicado: (2015)

Synaptic memory requires CaMKII
por: Tao, Wucheng, et al.
Publicado: (2021)

The role of calcium and CaMKII in sleep
por: Wang, Yuyang, et al.
Publicado: (2022)

Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca(2+)/CaMKII/CREB Signaling Pathway
por: Zhang, Yuqin, et al.
Publicado: (2017)

Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR–CaMKII–ERK/CREB signalling on consumption of aspartame in rat model
por: Iyaswamy, Ashok, et al.
Publicado: (2017)

Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes
por: Sun, Jianhong, et al.
Publicado: (2020)

κ-Opioid Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca(2+)/CaMKII/CREB Pathway
por: Ding, Guopeng, et al.
Publicado: (2021)

Does CaMKII decode Ca(2+) oscillations?
por: Pinto, Thiago M, et al.
Publicado: (2012)

Modulation by the GABA(B) receptor siRNA of ethanol-mediated PKA-α, CaMKII, and p-CREB intracellular signaling in prenatal rat hippocampal neurons
por: Lee, Hae Young, et al.
Publicado: (2011)

CASK and CaMKII function in Drosophila memory
por: Malik, Bilal R., et al.
Publicado: (2014)

CaMKII regulation of cardiac K channels
por: Mustroph, Julian, et al.
Publicado: (2014)

CaMKII in sinoatrial node physiology and dysfunction
por: Wu, Yuejin, et al.
Publicado: (2014)

CaMKII and stress mix it up in mitochondria
por: Joiner, Mei-ling A., et al.
Publicado: (2014)

CaMKII regulates the strength of the epithelial barrier
por: Shiomi, Ryo, et al.
Publicado: (2015)

Regulation of CaMKII signaling in cardiovascular disease
por: Mollova, Mariya Y., et al.
Publicado: (2015)

Physiological and unappreciated roles of CaMKII in the heart
por: Beckendorf, Jan, et al.
Publicado: (2018)

Architectural Dynamics of CaMKII-Actin Networks
por: Khan, Shahid, et al.
Publicado: (2019)

Exercise, CaMKII, and type 2 diabetes
por: Joseph, Jitcy S., et al.
Publicado: (2021)

CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation–transcription coupling
por: Wheeler, Damian G., et al.
Publicado: (2008)

Retracted: κ-Opioid Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca(2+)/CaMKII/CREB Pathway
por: Healthcare Engineering, Journal of
Publicado: (2022)

Purinergic stimulation of K(+)-dependent Na(+)/Ca(2+) exchanger isoform 4 requires dual activation by PKC and CaMKII
por: Yang, Xu, et al.
Publicado: (2013)

Non-canonical heterogeneous cellular distribution and co-localization of CaMKIIα and CaMKIIβ in the spinal superficial dorsal horn
por: Larsson, Max
Publicado: (2017)

Ischemic Injury-Induced CaMKIIδ and CaMKIIγ Confer Neuroprotection Through the NF-κB Signaling Pathway
por: Ye, Jing, et al.
Publicado: (2018)

Binding of Filamentous Actin to CaMKII as Potential Regulation Mechanism of Bidirectional Synaptic Plasticity by β CaMKII in Cerebellar Purkinje Cells
por: Pinto, Thiago M., et al.
Publicado: (2020)

Ca(2+)- and CaMKII-mediated processes in early LTP
por: Byth, Lachlan A
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_37mr97gidilfalb4hgrs68cb1k