C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α

Rationale: A C9orf72 hexanucleotide repeat expansion (GGGGCC) is the most common genetic origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Haploinsufficiency of C9orf72 has been proposed as a possible disease mechanism (loss-of-function mechanism). Additionally, the ab...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Wenzhong, Wang, Kexin, Wu, Yachen, Yan, Ge, Zhang, Chi, Li, Zhiqiang, Wang, Lianrong, Chen, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691347/
https://www.ncbi.nlm.nih.gov/pubmed/36438488
http://dx.doi.org/10.7150/thno.76138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691347/
https://www.ncbi.nlm.nih.gov/pubmed/36438488
http://dx.doi.org/10.7150/thno.76138

Ejemplares similares