Cargando…

C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α

Rationale: A C9orf72 hexanucleotide repeat expansion (GGGGCC) is the most common genetic origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Haploinsufficiency of C9orf72 has been proposed as a possible disease mechanism (loss-of-function mechanism). Additionally, the ab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Wenzhong, Wang, Kexin, Wu, Yachen, Yan, Ge, Zhang, Chi, Li, Zhiqiang, Wang, Lianrong, Chen, Shi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691347/ https://www.ncbi.nlm.nih.gov/pubmed/36438488 http://dx.doi.org/10.7150/thno.76138

Ejemplares similares

Unfolded protein response activation in C9orf72 frontotemporal dementia is associated with dipeptide pathology and granulovacuolar degeneration in granule cells
por: Gami‐Patel, Priya, et al.
Publicado: (2020)

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
por: Cheng, Weiwei, et al.
Publicado: (2018)

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS
por: Parameswaran, Janani, et al.
Publicado: (2023)

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
por: Boeynaems, Steven, et al.
Publicado: (2017)

Treatment implications of C9ORF72
por: Sha, Sharon J, et al.
Publicado: (2012)

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS
por: Goodman, Lindsey D., et al.
Publicado: (2019)

Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression
por: McGoldrick, Philip, et al.
Publicado: (2018)

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
por: Chitiprolu, Maneka, et al.
Publicado: (2018)

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
por: Chew, Jeannie, et al.
Publicado: (2019)

Neuroimaging features of C9ORF72 expansion
por: Yokoyama, Jennifer S, et al.
Publicado: (2012)

C9orf72 immunohistochemistry in Alzheimer's disease
por: Hortobágyi, Tibor
Publicado: (2012)

The Enigmatic Role of C9ORF72 in Autophagy
por: Nassif, Melissa, et al.
Publicado: (2017)

Neuronal Transcriptome from C9orf72 Repeat Expanded Human Tissue is Associated with Loss of C9orf72 Function
por: Liu, Elaine Y., et al.
Publicado: (2020)

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit
por: Sattler, Rita, et al.
Publicado: (2023)

Sumoylation of eIF4A2 affects stress granule formation
por: Jongjitwimol, Jirapas, et al.
Publicado: (2016)

A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
por: Sonobe, Yoshifumi, et al.
Publicado: (2021)

Circadian control of stress granules by oscillating EIF2α
por: Wang, Ruiqi, et al.
Publicado: (2019)

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers
por: Frick, Petra, et al.
Publicado: (2018)

The repeat length of C9orf72 is associated with the survival of amyotrophic lateral sclerosis patients without C9orf72 pathological expansions
por: Tang, Lu, et al.
Publicado: (2022)

A comparative bioinformatic analysis of C9orf72
por: Iyer, Shalini, et al.
Publicado: (2018)

RNA Misprocessing in C9orf72-Linked Neurodegeneration
por: Barker, Holly V., et al.
Publicado: (2017)

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A
por: Moens, Thomas G., et al.
Publicado: (2019)

FDG-PET in presymptomatic C9orf72 mutation carriers
por: Popuri, Karteek, et al.
Publicado: (2021)

Zika virus inhibits eIF2α-dependent stress granule assembly
por: Amorim, Raquel, et al.
Publicado: (2017)

DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene
por: Thys, Ryan Griffin, et al.
Publicado: (2015)

C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers
por: Rizzu, Patrizia, et al.
Publicado: (2016)

Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features
por: Lorenzini, Ileana, et al.
Publicado: (2023)

Assessment of psychiatric changes in C9ORF72 frontotemporal dementia
por: Hornberger, Michael
Publicado: (2012)

C9ORF72 expansion in a family with bipolar disorder
por: Meisler, Miriam H, et al.
Publicado: (2013)

Age-related penetrance of the C9orf72 repeat expansion
por: Murphy, Natalie A., et al.
Publicado: (2017)

Gyrification abnormalities in presymptomatic c9orf72 expansion carriers
por: Caverzasi, Eduardo, et al.
Publicado: (2019)

C9ORF72: What It Is, What It Does, and Why It Matters
por: Smeyers, Julie, et al.
Publicado: (2021)

C9ORF72 suppresses JAK-STAT mediated inflammation
por: Pang, Weilun, et al.
Publicado: (2023)

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α
por: Novoa, Isabel, et al.
Publicado: (2001)

Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansion()
por: Waite, Adrian J., et al.
Publicado: (2014)

C9orf72 in myeloid cells suppresses STING-induced inflammation
por: McCauley, Madelyn E., et al.
Publicado: (2020)

Large G3BP-induced granules trigger eIF2α phosphorylation
por: Reineke, Lucas C., et al.
Publicado: (2012)

Comparative Analysis of C9orf72 and Sporadic Disease in a Large Multicenter ALS Population: The Effect of Male Sex on Survival of C9orf72 Positive Patients
por: Trojsi, Francesca, et al.
Publicado: (2019)

Involvement of striatal motoric subregions in familial frontotemporal dementia with parkinsonism harboring the C9orf72 repeat expansions
por: Liu, Li, et al.
Publicado: (2022)

Dystrophic neurites express C9orf72 in Alzheimer's disease brains
por: Satoh, Jun-ichi, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1tde9pk11sevrtv7u5luvga0hk