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C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α

Rationale: A C9orf72 hexanucleotide repeat expansion (GGGGCC) is the most common genetic origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Haploinsufficiency of C9orf72 has been proposed as a possible disease mechanism (loss-of-function mechanism). Additionally, the ab...

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Detalles Bibliográficos
Autores principales:	Zheng, Wenzhong, Wang, Kexin, Wu, Yachen, Yan, Ge, Zhang, Chi, Li, Zhiqiang, Wang, Lianrong, Chen, Shi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691347/ https://www.ncbi.nlm.nih.gov/pubmed/36438488 http://dx.doi.org/10.7150/thno.76138

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