Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression of Notch and TGF-β signaling

Rationale: Extracellular matrix (ECM) remodeling, a key pathological feature in diabetic cardiomyopathy (DCM), is triggered by oxidative stress, inflammation, and various metabolic disorders in the heart. Cardiac fibroblasts (CFs) are the primary source of ECM proteins and the ultimate effector cell...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Cao, Yang, Zheng, Rui, Xiong, Zhenyu, Zhu, Zhengru, Gao, Fanya, Man, Wanrong, Duan, Yu, Lin, Jie, Zhang, Xuebin, Wu, Dexi, Jiang, Mengyuan, Zhang, Xiao, Li, Congye, Gu, Xiaoming, Fan, Yanhong, Sun, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691359/
https://www.ncbi.nlm.nih.gov/pubmed/36438502
http://dx.doi.org/10.7150/thno.77043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691359/
https://www.ncbi.nlm.nih.gov/pubmed/36438502
http://dx.doi.org/10.7150/thno.77043

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