circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR

Rational: Senescence is a major aging process that contributes to the development of cardiovascular diseases, but the underlying molecular mechanisms remain largely unknown. One reason is due to the lack of suitable animal models. We aimed to generate a cardiomyocyte (CM)-specific senescent animal m...

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Detalles Bibliográficos
Autores principales: Ding, Fengzhi, Lu, Lin, Wu, Chengjie, Pan, Xiangbin, Liu, Bin, Zhang, Yu, Wang, Yanli, Wu, Weiliang, Yan, Bing, Zhang, Yuqing, Yu, Xi-Yong, Li, Yangxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691369/
https://www.ncbi.nlm.nih.gov/pubmed/36438474
http://dx.doi.org/10.7150/thno.77630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691369/
https://www.ncbi.nlm.nih.gov/pubmed/36438474
http://dx.doi.org/10.7150/thno.77630

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