A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry

MHC restriction, which describes the binding of TCRs from CD4(+) T cells to class II MHC proteins and TCRs from CD8(+) T cells to class I MHC proteins, is a hallmark of immunology. Seemingly rare TCRs that break this paradigm exist, but mechanistic insight into their behavior is lacking. TIL1383I is...

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Detalles Bibliográficos
Autores principales: Singh, Nishant K., Alonso, Jesus A., Devlin, Jason R., Keller, Grant L. J., Gray, George I., Chiranjivi, Adarsh K., Foote, Sara G., Landau, Lauren M., Arbuiso, Alyssa G., Weiss, Laura I., Rosenberg, Aaron M., Hellman, Lance M., Nishimura, Michael I., Baker, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691722/
https://www.ncbi.nlm.nih.gov/pubmed/36424374
http://dx.doi.org/10.1038/s41467-022-34896-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691722/
https://www.ncbi.nlm.nih.gov/pubmed/36424374
http://dx.doi.org/10.1038/s41467-022-34896-0

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