HDAC1/3-dependent moderate liquid–liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation

Methyltransferase-like protein 3 (METTL3) plays critical roles in acute myeloid leukemia (AML) progression, however, the mechanism of abnormal overexpression of METTL3 in AML remain elusive. In the current study, we uncovered that Yin Yang 1 (YY1) binds to the promoter region of METTL3 as a transcri...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Meng, Li, Mingying, Xia, Yuan, Li, Guosheng, Su, Xiuhua, Wang, Dongmei, Ye, Jingjing, Lu, Fei, Sun, Tao, Ji, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691727/
https://www.ncbi.nlm.nih.gov/pubmed/36424383
http://dx.doi.org/10.1038/s41419-022-05435-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691727/
https://www.ncbi.nlm.nih.gov/pubmed/36424383
http://dx.doi.org/10.1038/s41419-022-05435-y

Ejemplares similares