Late-long-term potentiation magnitude, but not Aβ levels and amyloid pathology, is associated with behavioral performance in a rat knock-in model of Alzheimer disease

Cleavage of Amyloid precursor protein by β- and γ-secretases lead to Aβ formation. The widely accepted pathogenic model states that these mutations cause AD via an increase in Aβ formation and accumulation of Aβ in Amyloid plaques. APP mutations cause early onset familial forms of Alzheimer’s diseas...

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Detalles Bibliográficos
Autores principales: Yesiltepe, Metin, Yin, Tao, Tambini, Marc D., Breuillaud, Lionel, Zehntner, Simone P., D’Adamio, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691854/
https://www.ncbi.nlm.nih.gov/pubmed/36438008
http://dx.doi.org/10.3389/fnagi.2022.1040576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691854/
https://www.ncbi.nlm.nih.gov/pubmed/36438008
http://dx.doi.org/10.3389/fnagi.2022.1040576

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