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Biophysical insights into glucose-dependent transcriptional regulation by PDX1

The pancreatic and duodenal homeobox 1 (PDX1) is a central regulator of glucose-dependent transcription of insulin in pancreatic β cells. PDX1 transcription factor activity is integral to the development and sustained health of the pancreas; accordingly, deciphering the complex network of cellular c...

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Detalles Bibliográficos
Autores principales: Usher, Emery T., Showalter, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691942/
https://www.ncbi.nlm.nih.gov/pubmed/36272648
http://dx.doi.org/10.1016/j.jbc.2022.102623