Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes

UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of limitations in conventional cloning technique...

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Detalles Bibliográficos
Autores principales: Kobayashi, Kaoru, Deguchi, Tsuneo, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Nakamura, Kazuomi, Kurihara, Atsushi, Oshimura, Mitsuo, Kazuki, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692130/
https://www.ncbi.nlm.nih.gov/pubmed/36424908
http://dx.doi.org/10.1002/prp2.1030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692130/
https://www.ncbi.nlm.nih.gov/pubmed/36424908
http://dx.doi.org/10.1002/prp2.1030

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