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Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes
UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of limitations in conventional cloning technique...
Autores principales: | Kobayashi, Kaoru, Deguchi, Tsuneo, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Nakamura, Kazuomi, Kurihara, Atsushi, Oshimura, Mitsuo, Kazuki, Yasuhiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692130/ https://www.ncbi.nlm.nih.gov/pubmed/36424908 http://dx.doi.org/10.1002/prp2.1030 |
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