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p62/Sqstm1 rescue in muscle retards the progression of steatohepatitis in p62/Sqstm1-null mice fed a high-fat diet

Introduction: Obesity is a risk factor for many diseases because it leads to a reduction in skeletal muscle mass and promotes insulin resistance. p62/Sqstm1-knockout mice are a model of metabolic syndrome; show obesity, insulin resistance, and non-alcoholic fatty liver (NAFL); and develop non-alcoho...

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Detalles Bibliográficos
Autores principales: Miura, Ikuru, Okada, Kosuke, Ishii, Akiko, Warabi, Eiji, Watahiki, Takahisa, To, Keii, Shimano, Hitoshi, Ariizumi, Shunichi, Shoda, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692207/
https://www.ncbi.nlm.nih.gov/pubmed/36439272
http://dx.doi.org/10.3389/fphys.2022.993995