Tag-Free SARS-CoV-2 Receptor Binding Domain (RBD), but Not C-Terminal Tagged SARS-CoV-2 RBD, Induces a Rapid and Potent Neutralizing Antibody Response

Recombinant proteins are essential in the development of subunit vaccines. In the design of many recombinant proteins, polyhistidine residues are added to the N- or C-termini of target sequences to facilitate purification. However, whether the addition of tag residues influences the immunogenicity o...

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Detalles Bibliográficos
Autores principales: Lin, Ting-Wei, Huang, Ping-Han, Liao, Bo-Hung, Chao, Tai-Ling, Tsai, Ya-Min, Chang, Shih-Chung, Chang, Sui-Yuan, Chen, Hui-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692485/
https://www.ncbi.nlm.nih.gov/pubmed/36366348
http://dx.doi.org/10.3390/vaccines10111839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692485/
https://www.ncbi.nlm.nih.gov/pubmed/36366348
http://dx.doi.org/10.3390/vaccines10111839

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